COMPARATIVE STUDY OF EXTRA-AMNIOTIC PROSTAGLANDIN F2 AND INCREASING INTRAVENOUS OXYTOCIN INFUSION FOR TERMINATION OF PREGNANCY

Abstract

Military Hospital Rawalpindi from January 2000 to December 2000 to investigate the effectiveness of Prostaglandin F2a by extra amniotic route and to determine its side effects, while comparing it with intra venous Oxytocin infusion .Out of a total of 554 patients, 196 were given PGF2a extra amniotically (Group A),and 358 patients were given I/V Oxytocin infusion. All patients in Group ‘A’ aborted within 29 hours, while there were 8.66% (31)failures in the Group ‘B’ and the remaining 327 patients aborted/ delivered within 36 hours. The mean induction to delivery interval was 11.49 ± 6.11 hours in the PGF2a and 18.20 ± 8.00 hours in the oxytocin group. Delivery/ abortion within 24 hours was 93.88% Vs 69.55% p<0.0001 , complete expulsion rates of 76.53% Vs 68.46% and the complication rates of 7.14% (14) Vs 17.60% (63) in the PGF2a Vs Oxytocin groups were also significant. Satisfaction with management was much higher in the PGF2a 97.45 % (191) Vs 78.21% (280) p<0.0001 in the Oxytocin group. So PGF2a by this route is superior to Oxytocin in terms of shorter induction to delivery interval, low prevalence of side effects, stronger haemostatic effect, safety and efficacy.