VALIDITY OF ULTRASOUND IN DIAGNOSIS OF LIVER FIBROSIS RESULTING FROM CHRONIC VIRAL HEPATITIS

Authors

  • Muhammad Nafees CMH Quetta
  • Ghulam Abbas Combined Military Hospital Quetta
  • Muhammad Saqib Combined Military Hospital Quetta

Keywords:

Chronic viral hepatitis, Fibrosis, Ultrasound, Validity

Abstract

Objective: To determine the validity of ultrasound in diagnosis of liver fibrosis associated with chronic viral hepatitis, considering histopathological findings as gold standard.
Study Design: Validation study.
Place and Duration of Study: Department of Radiology, Military hospital Rawalpindi, from March 2007 to February 2008.
Patients and Methods: Patients with positive laboratory findings of viral hepatitis were sonographically evaluated in Radiology department in lying position with 2–5 MHz frequency convex and 5–12 MHz frequency linear probes of Aloka prosound (ssd) 5500 ultrasound machine. An Ultrasound scoring system using both the low and high frequency probes was performed by evaluating the edge, surface and parenchymal texture of the liver. Each score was obtained by evaluating three parameters; the bluntness of the liver edge, the irregularity of the surface and coarseness of the parenchymal texture were evaluated and then compared with the histological findings.
Results: Amongst 50 patients with history of chronic viral hepatitis, 31(62%) were males and 19 (38%) were females. Ages of patients ranged between 26-60 years (mean 40.8 years). The US (ultrasound) accumulated scores of the liver edge, liver surface and liver parenchymal texture were compared with the fibrosis stage obtained based on the biopsy findings. The accumulated US scores of these three parameters (fibrosis stage 0-IV- No fibrosis, mild, moderate and sever fibrosis) however, were found to be the most reliable indicator. Thirty Two (64%) patients showed true positive, 4 patients (08%) showed false positive, 09 (18%) patients showed true negative and 05 patients (10%) patients showed false negative results. (Table .1)Sensitivity, Specificity, positive predictive values, Negative predictive values and accuracy of Ultrasound in diagnosis of liver fibrosis were calculated to be 86.48%, 69.23%, 88.88 %, 64.28% and 82% respectively. (Table.2)
Conclusion: Ultrasound evaluation of the liver fibrosis stage based on the scoring system using both low and high frequency probes has been found to be a reliable and effective alternative to the histological staging in chronic liver disease.

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Published

31-12-2011

How to Cite

Nafees, M., Abbas, G., & Saqib, M. (2011). VALIDITY OF ULTRASOUND IN DIAGNOSIS OF LIVER FIBROSIS RESULTING FROM CHRONIC VIRAL HEPATITIS. Pakistan Armed Forces Medical Journal, 61(4), 585–9. Retrieved from https://pafmj.org/PAFMJ/article/view/1143

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Original Articles

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