TY - JOUR AU - Zahid, Aqsa AU - Qamar, Khadija AU - Qamar, Abdullah AU - Faisal, Tayyaba AU - Iftikhar, Zubia AU - Saleem, Saba PY - 2022/06/26 Y2 - 2024/03/29 TI - Prolotherapy Improves Anatomical and Clinical Outcomes in Monosodium Iodoacetate Induced Model of Osteoarthritis JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 3 SE - Original Articles DO - 10.51253/pafmj.v72i3.8631 UR - https://pafmj.org/PAFMJ/article/view/8631 SP - 904-07 AB - <p><strong>Objective:</strong> To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle in Monosodium Iodoacetate (MIA) induced osteoarthritis in the rat knee joint.</p><p><strong>Study Design:</strong> Laboratory-based experimental study.</p><p><strong>Place and Duration of Study:</strong> Department of Anatomy, Army Medical College, Rawalpindi in collaboration with the National Institute of Health (NIH), Islamabad and Pathology Lab Pak Emirates Rawalpindi, Pakistan, from Aug to Nov 2021.</p><p><strong>Methodology:</strong> Thirty male Sprague Dawley rats were randomly divided into three groups (n=10 in each group). The control group was Group-A. To induce osteoarthritic changes in Group-B, a single dose of 1mg Monosodium Iodoacetate was injected intra-articularly into the right knee. Group-C received a single dose of 1mg Monosodium Iodoacetate injection in the right knee intra articularly to induce osteoarthritic changes, and was followed by 0.1ml Prolotherapy (3ml of 25% dextrose, 2ml of 2% Xylocaine, 1ml of injection thiamine, and 1ml of injection Methylcobalamin) at 2, 6 and 10 weeks intra articularly into the right knee joint.&nbsp; Before euthanasia, Pain scoring schemes for gait in rats of all groups were done at 0, 2 and 14 weeks.</p><p><strong>Results:</strong> The present study concluded that prolotherapy improved the gait cycle pain score in experimental group C (p-value 0.001 on the intergroup comparison at two weeks and 14 weeks while p-value 0.001 when compared pain score within the Group C at 0, 2 and 14 weeks).</p><p><strong>Conclusion:</strong> Prolotherapy had ameliorative effects on the pain score of the gait cycle in experimental Group C on Monosodium Iodoacetate......</p> ER -