TY - JOUR AU - hussain, Nabiha AU - Ali, Shabana AU - Bano, Maleeha AU - Khursheed, Tooba AU - Beenish, Huma AU - Bano, Syeda Sara PY - 2022/09/07 Y2 - 2024/03/29 TI - Protective Effect of Selenium and Zinc Against Dehp Induced Toxicity in the Thyroid Gland of Rats JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 4 SE - Original Articles DO - 10.51253/pafmj.v72i4.8393 UR - https://pafmj.org/PAFMJ/article/view/8393 SP - 1424-27 AB - <p><strong>Objective:</strong> To compare the efficacy of Selenium and Zinc in improving histological features on DEHP-induced toxicity in the thyroid gland of rats.</p><p><strong>Design of study:</strong> Laboratory based experimental study.</p><p><strong>Place and Duration of Study:</strong> Anatomy Department of Islamic International Medical College with the National Institute of Health (NIH), Islamabad Pakistan cooperation from Sep 2019 to Sep 2020.</p><p><strong>Methodology:</strong> Forty, eight weeks old rats were divided into four groups, each containing ten male rats. In control, Group-A rats were on the standard diet. In Group-B, rats were given orally 500mg/kg/day DEHP. In Group-C rats were given 500mg/kg/day DEHP and 1mg/kg/day Selenium orally. In Group-D rats were given 500mg/kg/day DEHP and 5mg/kg/day Zinc orally. After 28 days, rats were dissected, and the thyroid gland was removed. Histological parameters, vacuolization and number of follicular cells were observed with H and E stining among control and experimental groups.</p><p><strong>Results:</strong> In Group-B, 50% of rats showed severe vacuolization. In Group-C, 60% of rats showed minimal vacuolization. In Group- D, 40% of rats showed minimally, and 40% of rats showed mild vacuolization. Among quantitative parameters, the number of follicular cells was conserved more by Selenium than Zinc.</p><p><strong>Conclusion:</strong> Selenium and Zinc have a protective effect on thyroid histological changes caused by DEHP, but Selenium shows better conservation than zinc on thyroid histology.</p> ER -