TY - JOUR AU - Ali, Rida AU - Mahmud, Shahid PY - 2023/02/24 Y2 - 2024/03/29 TI - Nasal High-Frequency Oscillatory Ventilation versus Nasal Intermittent Positive Pressure Ventilation In Pre-terms With Respiratory Distress Syndrome During Early Neonatal Period: A Randomized Controlled Trial JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 73 IS - 1 SE - Original Articles DO - 10.51253/pafmj.v73i1.8186 UR - https://pafmj.org/PAFMJ/article/view/8186 SP - 151-54 AB - <p><strong>Objective:</strong> To determine the effectiveness of NHFOV versus NIPPV in reducing the need for invasive mechanical ventilation in preterm neonates with RDS (moderate-severe) during the first seven days of the life of neonate.</p><p><strong>Study Design:</strong> Randomized controlled study (ACTRN: 12622000291785).</p><p><strong>Place and Duration of Study:</strong> Neonatal Unit, PNS Shifa Hospital, Karachi Pakistan, from Jan to Aug 2021.</p><p><strong>Methodology:</strong> Forty-eight preterm neonates, with the gestational age of 27 weeks to 34 weeks with Respiratory distress Syndrome, were randomized to NHFOV Group (n=24) and NIPPV Group (n=24). The primary outcome was the need for invasive mechanical ventilation (IMV). The secondary outcomes were the duration of hospitalization, non-invasive respiratory support, mortality, abdominal distention, pneumothorax, need for surgery for patent ductus arteriosus, spontaneous intestinal perforation, and necrotizing enterocolitis, intraventricular haemorrhageā‰„ Grade-3, bronchopulmonary dysplasia, retinopathy of prematurity Stage-3.</p><p><strong>Results:</strong> There was no significant difference between NHFOV (64.7%) versus NIPPV (35.3%) groups in need of Invasive Mechanical Ventilation (p=0.13). Secondary outcomes were not significant between the two groups, air leak (p=0.31),necrotising enterocolitis (p=1.00), broncho-pulmonary dysplasia (p=0.31), retinopathy of prematurity (p=0.15).There was no intraventricular haemorrhage found between the two groups.</p><p><strong>Conclusion:</strong> Nasal high-frequency oscillatory ventilation was less statistically significant than NIPPV in reducing the need for invasive mechanical ventilation in the initial seven days of life in neonates with Respiratory distress syndrome.</p> ER -