TY - JOUR AU - Mushtaq, Saadiya AU - Din, Nasir Ud AU - Shah, Abid Hussain AU - Riaz, Omair AU - Azam, Khalid AU - Khan, Sara Waqar PY - 2022/06/26 Y2 - 2024/03/29 TI - Association of Time-Lines of COVID-19 Seropositivity with Antibody Ratio Levels JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 3 SE - Original Articles DO - 10.51253/pafmj.v72i3.7173 UR - https://pafmj.org/PAFMJ/article/view/7173 SP - 1023-26 AB - <p><strong>Objective:</strong> To determine the persistence of IgG antibodies against SARS-CoV-2 and the association of timelines of COVID-19 seropositivity with antibody ratio levels.</p><p><strong>Study Design:</strong> Cross-sectional study.</p><p><strong>Place and Duration of Study:</strong> Combined Military Hospital, Lahore, from Apr to Sep 2020.</p><p><strong>Methodology:</strong> The serum of 250 patients recovered from COVID-19 was collected to detect anti-SARS-COV-2 IgG antibodies. Anti-SARS Cov-2 IgG was measured by Semi-Quantitative Enzyme-Linked Immuno-Sorbent Assay (ELISAs), and the association of timelines of COVID-19 seropositivity with antibody ratio levels was determined.</p><p><strong>Results:</strong> Out of 250 study participants, males were 220 (88%) while females were 30 (12%), mean age being 35.25 years ± 9.096 years. In the timeline of 31-60 days after the first positive COVID-19 PCR, 27 out of 44 (61%) were seropositive. In the 61-90 days’ timeline, 79 out of 155 (51%) were seropositive, in the timeline of 91-120 days after the first positive PCR, 52 out of 76 (68%) were seropositive, and in the timeline of 121-150 days, 12 out of 15 (80%) of the study participants were seropositive for COVID-19.</p><p><strong>Conclusion:</strong> Serological IgG immune response against SARS-CoV-2 persists up to five months after active COVID-19 infection in most individuals in the Pakistani population.</p> ER -