TY - JOUR AU - Saleem, Summaya AU - Raza, Naeem AU - Saleem, Nida AU - Ullah, Saleem AU - Yasmin, Ghazala AU - Yousaf, Farrah PY - 2023/02/23 Y2 - 2024/03/29 TI - Efficacy of Topical 0.05% Isotretinoin Gel Versus 0.1% Adapalene Gel in The Treatment of Mild to Moderate Acne Vulgaris JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 73 IS - 1 SE - Original Articles DO - 10.51253/pafmj.v73i1.6472 UR - https://pafmj.org/PAFMJ/article/view/6472 SP - 107-10 AB - <p><strong>Objective:</strong> To compare the efficacy of topical 0.05% Isotretinoin gel versus 0.1% Adapalene gel in treating mild to moderate acne vulgaris.</p><p><strong>Study Design:</strong> Quasi-Experimental study.</p><p><strong>Place and Duration of Study:</strong> Department of Dermatology, Pak Emirates Military Hospital (PEMH), Rawalpindi Pakistan, From Feb to Jul 2018.</p><p><strong>Methodology:</strong> A total of ninety-two patients aged 12 to 25 years with mild to moderate facial acne vulgaris were enrolled and divided into two treatment Groups, Group-A (0.05% Isotretinoin Gel) and Group-B (0.1% Adapalene Gel). Efficacy was measured at 12 weeks post-treatment.</p><p><strong>Results:</strong> Treatment was found efficacious in 84.8% (n=39/46) of patients in Group-A and 50.0% (n=23/46) of patients in Group-B (p= 0.001). There were similar results when treatment efficacy in both Groups was disease severity. In all cases,efficacy was better in Group-A (p&lt;0.05).</p><p><strong>Conclusions:</strong> The efficacy of topical 0.05% Isotretinoin gel was better than topical 0.1% Adapalene gel for treating mild to moderate acne vulgaris.</p> ER -