TY - JOUR AU - Shahid, Aisha AU - Haider, Ghulam AU - Memon, Paras AU - Beg, Shumyla AU - Shahzadi, Mehwish AU - Abbas, Kiran PY - 2021/10/31 Y2 - 2024/03/29 TI - ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER: Steroid Receptor Expression in Endometrial Cancer JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 71 IS - 5 SE - Original Articles DO - 10.51253/pafmj.v71i5.5802 UR - https://pafmj.org/PAFMJ/article/view/5802 SP - 1875-79 AB - <p><strong>Objective:</strong> To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer.</p><p><strong>Study Design:</strong> Prospective observational study.</p><p><strong>Place and Duration of Study:</strong> Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019.</p><p><strong>Methodology:</strong> A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test.</p><p><strong>Results:</strong> The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p&lt;0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p&lt;0.001.</p><p><strong>Conclusion:</strong> Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.</p> ER -