TY - JOUR AU - Bibi, Afshan AU - Asif, Naveed AU - Haroon, Zujaja Hina AU - Ijaz, Aamir AU - Nawaz, Asif AU - Atif, Qurat Ul Ain PY - 2020/10/30 Y2 - 2024/03/28 TI - VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 70 IS - 5 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/5558 SP - 1327-31 AB - <p><strong>Objective:</strong> To determine clinical decision limits (cut off points) for vitamin D deficiency based on secondary hyperparathyroidism.</p><p><strong>Study Design:</strong> Cross sectional study.</p><p><strong>Place and Duration of Study:</strong> This study was conducted in the Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), from Dec 2016 to May 2017.</p><p><strong>Methodology:</strong> One hundred and sixteen subjects, aged 18 to 60 years, of either gender, with vitamin D levels less than 50nmol/L, were consecutively included in the study.</p><p><strong>Results:</strong> Serum 25(OH) D had inverse relation with plasma iPTH level (r=-0.597, p&lt;0.0001). Thirty five percent of the subjects with vitamin D level below 50nmol/L had secondary hyperparathyroidism. However, the frequency of secondary hyperparathyroidism was 52% in subjects with 25 (OH) D level less than 25nmol/L compared with 28% having serum vitamin D levels of 25-40nmol/L. None of the patient with Vitamin D level above 40nmol/L had secondary hyperparathyroidism. Receiver operating characteristic (ROC) curve showed that 25(OH) D level of 25.5nmol/L as an optimal cut off level for vitamin D deficiency based on Secondary Hyperparathyroidism with area under the curve (AUC) was 0.761.</p><p><strong>Conclusion:</strong> High frequency of secondary hyperparathyroidism in adults with vitamin D levels under 25nmol/L necessitates reconsideration of vitamin D cutoff limit for bone health.</p> ER -