TY - JOUR AU - Hina, Urooj AU - Choudry, Abeera AU - Saeed, Saira AU - Khanam, Faiza AU - Urooj, Uzma PY - 2022/11/10 Y2 - 2024/03/29 TI - Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 5 SE - Original Articles DO - 10.51253/pafmj.v72i5.5383 UR - https://pafmj.org/PAFMJ/article/view/5383 SP - 1576-80 AB - <p><strong>Objective:</strong> To determine the association between low Vitamin-D status and risk of pre-eclampsia and preterm birth in women using low-dose Aspirin in the tertiary care setting.</p><p><strong>Study Design:</strong> Prospective comparative study.</p><p><strong>Place and Duration of Study:</strong> Gynecology and Obstetrics Department, Pak Emirates Military Hospital, Rawalpindi Pakistan from Sep 2018 to Sep 2019.</p><p><strong>Methodology:</strong> A total of 383 pregnant women were divided into three Groups. Pregnant women were included based on the criteria; if one of the five high-risk factors or more than one moderate risk factors were met. High-risk factors were; 1) Type-1 or 2 diabetes mellitus, 2) chronic hypertension, 3) hypertensive disease in previous pregnancy, 4) autoimmune disease such as systemic lupus erythematous or antiphospholipid syndrome, 5) chronic kidney disease.</p><p><strong>Results:</strong> There were 127 pregnant women in Group-1 with Vitamin-D deficiency. In Group-2, there were pregnant women with Vitamin-D insufficiency; in Group-3, there were 18 pregnant women with Vitamin-D sufficiency. The mean Vitamin-D level in Group-1 was 22.40±1.50 nmol/L, the mean Vitamin-D level in Group-2 was 32.82±9.80nmol/L and in Group-3 mean Vitamin-D level was 76.63±8.00 nmol/L. Early onset pre-eclampsia, chronic hypertension with superimposed pre-eclampsia,gestational diabetes, spontaneous-vaginal delivery and delivery at term were found to statistically significant among the Groups (p&lt;0.05).</p><p><strong>Conclusion:</strong> We aimed to determine whether vitamin D status was linked with high-risk pregnancies, which could overshadow the impact of vitamin D under existing conditions. Our findings help relate the status and pre-eclampsia of maternal vitamin D to preterm birth.</p> ER -