TY - JOUR AU - Furqan, Warda AU - Tayyab, Nadia AU - Ali, Sakhawat AU - Mirza, Irfan Ali AU - Naseem, Arshad AU - Din, Hafeez Ud PY - 2020/07/30 Y2 - 2024/03/29 TI - COMPARISON OF INFLAMMATORY MARKERS AS PREDICTORS OF BLOOD STREAM INFECTIONS IN POSITIVE BLOOD CULTURES OF COVID-19 PATIENTS IN A TERTIARY CARE HOSPITAL JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 70 IS - 1 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/4876 SP - S206-11 AB - <p><strong>Objective:</strong> To determine the correlation of positive blood cultures in septicemic COVID-19 patients with significantly raised serum inflammatory markers C-reactive protein, lactate dehydrogenase and lactate levels.</p><p><strong>Study Design:</strong> Cross-sectional study.</p><p><strong>Place and Duration of Study:</strong> Department of Microbiology, Pak Emirates Military Hospital (PEMH) Rawalpindi from Apr 2020 to Jun 2020.</p><p><strong>Methodology:</strong> This study included specimens from 69 adult COVID-19 hospitalized patients with moderate to severe infection. Blood cultures of cases with suspected blood stream infections were processed. Positive blood cultures were compared with markedly raised inflammatory markers.</p><p><strong> Results:</strong> From a of total 69 blood culture specimen, 36 (52.17%) showed bacterial growth whereas 33 (47.82%) had no bacterial growth. The values of serum C-reactive proteins were in moderate to severe range (≥10mg/l) for 33 (91.66%) out of 36 positive blood cultures. The Lactate dehydrogenase values for 34 (94.44%) out of 36 positive blood cultures were in moderate to severe range (≥300U/L). Serum lactate values for 30 (83.33%) out of 36 patients with positive blood cultures were in moderate to severe range (≥2.21mmol/l). This result was statistically significant.</p><p><strong>Conclusion:</strong> Serum C-reactive proteins, Lactate dehydrogenase and lactate were markedly high in patients with blood stream infections in patients with COVID-19. These inflammatory markers can be used, not only as early predictors of secondary bacterial infections in COVID-19 patients, but can also help to formulate empirical treatment.</p> ER -