TY - JOUR AU - Haider, Rehan AU - Masud, Mannan AU - Hasnain, Mohammad Rashhid AU - Khan, Muhammad Tariq AU - Wyne, Adeel AU - Ehsan, Ayesha AU - Kazmi, Zahra AU - Raza, Syed Asim PY - 2022/08/31 Y2 - 2024/03/29 TI - Post-Operative Infection Rate Between Single Dose Versus Multiple Dose Antibiotic Therapyin Patients Undergoing Laparoscopic Cholecystectomy JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 4 SE - Original Articles DO - 10.51253/pafmj.v72i4.4342 UR - https://pafmj.org/PAFMJ/article/view/4342 SP - 1224-27 AB - <p><strong>Objective:</strong> To compare the frequency of post-operative infection rate between single dose versus multiple dose antibiotic therapy in patients undergoing laparoscopic cholecystectomy.</p><p><strong>Study Design:</strong> Comparative prospective study.</p><p><strong>Place and Duration of Study:</strong> Surgical Department, Combined Military Hospital, Lahore Pakistan from Oct 2017 to Feb 2020.</p><p><strong>Methodology:</strong> Patients of both genders undergoing laparoscopic cholecystectomy for simple cholelithiasis were included. Group-A patients underwent laparoscopic cholecystectomy using single-dose prophylactic antibiotic therapy with 2-gram 3rd generation cephalosporin at the time of induction of anaesthesia. In contrast, Group-B patients underwent laparoscopic cholecystectomy using 2-grams of 3rd generation Cephalosporin intravenously at the time of induction of anaesthesia followed by intravenous 1-gram Ceftriaxone two doses 12 hours apart. All patients were followed up on the first postoperative day, and then 1-week and 2-week follow up were done for any surgical site infection.</p><p><strong>Results:</strong> Patients in Group-A had a mean age of 37.12±6.53 years, while patients in Group-B had a mean age of 37.74±6.40 years. The post-operative infection rate in Group-A (single dose antibiotic therapy) was seen in 08 (4.28%), while in Group-B (multiple dose antibiotic therapies) was seen in 18 (9.63%) patients (p-value = 0.042).</p><p><strong>Conclusion:</strong> This study concluded that the single-dose prophylactic antibiotic is as good as multiple-dose antibiotic therapy used as prophylaxis for the prevention of post-operative infection rate among patients with cholecystectomy done via the laparoscopic method.</p> ER -