TY - JOUR AU - Javed, Rabia AU - Akhtar, Noreen AU - Hassan, Usman AU - Azam, Mohammad AU - Loya, Asif AU - Hussain, Mudassir AU - Hameed, Maryam AU - Butt, Sumera AU - Mushtaq, Sajid PY - 2020/04/30 Y2 - 2024/03/29 TI - IDH-1, ATRX AND 1P19Q CO-DELETION IN DIFFUSE GLIOMAS JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 70 IS - 2 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/4235 SP - 571-77 AB - <p><strong>Objective:</strong> To stratify diffuse gliomas into subtypes including diffuse astrocytomas, oligodendrogliomas and glioblastomas based on recent molecular updates and assess their frequencies in our local subpopulation.</p><p><strong>Study Design:</strong> Cross-sectional study.</p><p><strong>Place and Duration of Study:</strong> Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, from Jun 2015 to Jul 2017</p><p><strong>Methodology:</strong> Two hundred and fourteen (n=214) cases of adult diffuse gliomas were evaluated. Clinical and morphological features like age, gender and type of tumor were quantified. Molecular studies including IDH 1 by antibody and PCR, ATRX by antibody and 1p/19q co-deletion by FISH were tested. Gliomas were subcategorised based on WHO 2016 guidelines.</p><p><strong>Results:</strong> Mean age of presentation was 39 years. Overall n=146/214 (68.2%) of the cases were completely classifiable including Diffuse Astrocytomas, Oligodendrogliomas and Glioblastomas. Out of the glioblastomas (n=81), 67/81(n=82.7%) were IDH Wild type and 14/81 (17.3%) were IDH Mutant.</p><p><strong>Conclusion:</strong> In this study, glioblastomas are the most frequent gliomas as categorized by current WHO molecular guidelines followed by diffuse astrocytomas. Oligodendrogliomas are the least common.</p> ER -