TY - JOUR AU - Akram, Muhammad AU - Bajwa, Saleem Pervaiz AU - ., Abdullah AU - Hussain, Akhtar AU - Safdar, C. Aqeel AU - Khan, Umer PY - 2020/04/30 Y2 - 2024/03/28 TI - THE EFFICACY OF APREPITANT (NK-1 RECEPTOR ANTAGONIST) AS PROPHYLAXIS FOR POSTOPERATIVE NAUSEA AND VOMITING JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 70 IS - 2 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/4174 SP - 281-85 AB - <p><strong>Objective:</strong> To assess the effectiveness of Aprepitant (NK-1 receptor antagonist) for prophylaxis of postoperative nausea and vomiting in middle aged female patients undergoing laparoscopic cholecystectomy under General Anesthesia.</p><p><strong>Study Design:</strong> Quasi-experimental study.</p><p><strong>Place and Duration of Study:</strong> Combined Military Hospital Lahore, from Jun 2018 to Dec 2018. Methodology: Four hundred American Society of Anesthesiologists (ASA) I and II middle aged female patients undergoing laparoscopic cholecystectomy under general anesthesia were recruited. Patients were divided into two groups of 200 each as ā€œAā€ (Aprepitant) and ā€œPā€ (Placebo). Forty miligrams Aprepitant was given to A-group patients, whereas P-group was given empty capsule. Patients were given standardized general anesthesia and were observed and documented for incidence and severity of early (0-2 hours) and delayed (2-24 hours) periods for episodes of postoperative nausea and vomiting.</p><p><strong>Results:</strong> In A-group 20 (10%) had nausea, 8 (4%) had vomiting. Only 4 (2%) needed rescue anti-emetic. In P-group 84 (42%) had nausea and 76 (38%) had vomiting, 21 (10.5%) needed rescue antiemetic. The difference between the two groups was found statistically significant.</p><p><strong>Conclusion:</strong> Preemptive use of Aprepitant (NK-1 receptor antagonist) reduces the incidence of postoperative nausea and vomiting and need for rescue anti-emetic.</p> ER -