TY - JOUR AU - Ali, Humaira AU - Alam, Junaid M AU - Naureen, Shazia PY - 2021/06/29 Y2 - 2024/03/29 TI - N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDES IN INFANTS AND CHILDREN WITH NON-CARDIAC DISEASES JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 71 IS - 3 SE - Original Articles DO - 10.51253/pafmj.v71i3.3781 UR - https://pafmj.org/PAFMJ/article/view/3781 SP - 840-43 AB - <p><strong>Objective:</strong> To evaluate the levels of N-terminal pro-B-type Natriuretic Peptide in infants and children with non-cardiac diseases especially respiratory diseases.</p><p><strong>Study Design:</strong> Cross-sectional study.</p><p><strong>Place and Duration of Study:</strong> Department of Chemical Pathology/Biochemistry Laboratory Services of Liaquat National Hospital Karachi Pakistan, from Dec 2018 to Nov 2019.</p><p><strong>Methodology:</strong> Infants and children admitted to the Pediatric department with non-cardiac diseases were included in the study. Non-probability consecutive sampling was done. Blood was taken and analyzed for N- terminal pro-B-type Natriuretic Peptide, Troponin I, urea, creatinine, Lactate dehydrogenase, Creatinine Kinase, lactate and sodium analysis.</p><p><strong>Results:</strong> Out of the 93 patients, 74 (80%) were diagnosed with respiratory disorders, with bronchopneumonia making up 54 (59%) Bronchiolitis 15 (17%) and 4% had miscellaneous respiratory diseases. Out of the remaining 20%, 8 (9%) patients were diagnosed with sepsis, and the remaining 11% were diagnosed with miscellaneous diseases. There was a positive correlation of N- terminal pro-B-type Natriuretic Peptide with Troponin I, urea, creatinine, Creatinine Kinase and Lactate dehydrogenase levels (p&lt;0.05).</p><p><strong>Conclusion:</strong> N- terminal pro-B-type Natriuretic Peptide levels were found to be raised in pediatric patients with non-cardiac diseases especially broncho-pneumonia and in future it may be used as a marker of bronchopneumonia in children.</p> ER -