TY - JOUR AU - Muhammad, Sardar AU - Fakhr, Amer AU - Manzar, Muhammad Adnan AU - Hakim, Farzana AU - Khan, Taimoor Ashraf AU - Ahmad, Bilal PY - 2019/12/18 Y2 - 2024/03/28 TI - FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 69 IS - 6 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/3632 SP - 1194-98 AB - <p><strong>Objective:</strong> To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein &amp; erythrocyte sedimentation rate).</p><p><strong>Study Design:</strong> Descriptive, cross-sectional study.</p><p><strong>Place and Duration of Study:</strong> Department of Rheumatology Pak Emirates Military Hospital, Rawalpindi for duration of 10 months from Jan 2018 to Oct 2018.</p><p><strong> Methodology:</strong> We included 100 cases of Ankylosing Spondylitis. Sample was selected by consecutive sampling technique and used “(Modified) New York Classification Criteria for Ankylosing Spondylitis”. Blood samples for C-reactive protein &amp; erythrocyte sedimentation rate and Human leukocyte antigen B-27 were analysed by the same pathologist. We analyzed the data by using SPSS version 20.</p><p><strong>Results:</strong> Mean age of cases was 25 ± 4.5 years. Seventy-seven patients were positive for Human leukocyte antigen B27 and 23 were negative. In 69% patients erythrocyte sedimentation rate was high and in 64% patients C-reactive protein was raised. In 33% patient there was only axial involvement while peripheral arthritis was present in 67% of patients and enthesitis in 60%. Only 5% patients have the uveitis (All positive for Human leukocyte antigen B-27). Only one patient had cardiac involvement.</p><p><strong> Conclusion:</strong> Ankylosing Spondylitis was found a common disease and study results showed similar trends of positive Human leukocyte antigen B-27 cases as in the rest of the world. Human leukocyte antigen B-27 has a strong statistically significant association with peripheral joint involvement and acute anterior uveitis.</p> ER -