TY - JOUR AU - Afzal, Warda AU - Saba, Ameena AU - Zaidi, Syed Taqi Hasan AU - Siddiqui, Hamid Jamal AU - Tahir, Muhammad PY - 2022/10/30 Y2 - 2024/03/29 TI - Clinical Spectrum and Drug Sensitivity Pattern in Multi Drug-Resistant Typhoid Fever JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 72 IS - 5 SE - Original Articles DO - 10.51253/pafmj.v72i5.3594 UR - https://pafmj.org/PAFMJ/article/view/3594 SP - 1531-34 AB - <p><strong><em>Objectives:</em></strong> To study the clinical presentation, complications and drug sensitivity patterns of multi drugs- resistant enteric fever.</p><p><strong><em>Study Design:</em></strong> Prospective longitudinal study.</p><p><strong><em>Place and duration of study:</em></strong> Combined Military Hospital, Malir Cantt Karachi Pakistan, from Mar to Oct 2019.</p><p><strong><em>Methodology:</em></strong> A hundred cases of multi-drug resistant enteric fever were enrolled. Their demographic data, clinical and laboratory features and drug sensitivity pattern was recorded.</p><p><strong><em>Results:</em></strong> Out of 100 cases, 67 were within 5 to 11 years of age. Twenty-one patients presented with loose motion and splenomegaly each. Seventy cases had a fever of 1 to 2-weeks duration. Complications were seen in 42 cases, out of which hepatitis was most commonly observed (in 27 cases). Ciprofloxacin and Ceftriaxone sensitivity were found to be only 3% and 9%, respectively. Sensitivity to Azithromycin was 95%, while all cases were sensitive to Meropenem and Imipenem.</p><p><strong><em>Conclusion:</em></strong> Very high frequency of extensively drug-resistant typhoid fever was found. Most cases of enteric fever had a fever as the only presenting feature. Typhidot test has very low sensitivity.</p> ER -