TY - JOUR AU - Malik, Noureen AU - Masud, Hannan AU - Awan, Muhammad Manzoor PY - 2021/02/24 Y2 - 2024/03/28 TI - QUANTIFICATION OF RETINAL NERVE FIBER LAYER FOR EARLY DETECTION OF ANTERIOR VISUAL PATHWAY LESIONS JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 71 IS - 1 SE - Original Articles DO - 10.51253/pafmj.v71i1.3108 UR - https://pafmj.org/PAFMJ/article/view/3108 SP - 96-100 AB - <p><strong>Objective:</strong> To assess the role of quantification of retinal nerve fiber layer for early detection of anterior visual<br>pathway lesions.</p><p><strong>Study Design:</strong> Case-control study.</p><p><strong>Place and Duration of Study:</strong> Armed Forces Institute of Ophthalmology, Rawalpindi, from Jan to Jul 2019.</p><p><strong>Methodology:</strong> A total of 100 cases of anterior visual pathway lesions of varying clinical presentations were<br>included in the study. There were 100 matched controls who were selected from the community without any<br>ophthalmological abnormality using non-probability consecutive sampling technique. Retinal nerve fiber layer<br>(RNFL) thickness was measured with the help of optical coherence tomography in both the cases and controls.<br>Mean retinal nerve fiber layer values were compared in both the groups. Student’s t-test was applied to look for<br>any significant difference between the two groups.</p><p><strong>Results:</strong> Mean age of the patients was 39.14 ± 3.925 years while mean age of the controls was 39.23 ± 2.415 years. Mean retinal nerve fiber layer thickness in the case group was 72.21 ± 9.615 µm while on the control group was 101.34 ± 9.615 µm. A statistically significant difference was observed between cases and controls in terms of mean retinal nerve fiber layer thickness (p&lt;0.001). Subjects with retinal nerve fiber layer thickness &lt;85 µm were more likely to exhibit anterior visual pathway lesions (OR= 15.915 [6.278-40.346]; 95% CI, p&lt;0.001).</p><p><strong>Conclusion:</strong> Decreased retinal nerve fiber layer thickness can serve as a predictor for anterior visual pathway<br>lesions. Optical coherence tomography should be incorporated for routine screening of high-risk cases in order.........</p> ER -