TY - JOUR AU - Zaidi, Amber AU - Waheed, Palvasha AU - Rashid, Amir PY - 2017/10/30 Y2 - 2024/03/29 TI - THE RELATION OF C-REACTIVE PROTEIN, ERYTHROCYTE SEDIMENTATION RATE AND BODY MASS INDEX WITH DIABETIC RETINOPATHY IN PATIENTS ENROLLED FROM A TERTIARY CARE HOSPITAL: Diabetic Retinopathy JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 67 IS - 6 SE - Original Articles DO - UR - https://pafmj.org/PAFMJ/article/view/1097 SP - 926-29 AB - <p><strong>Objective:</strong>&nbsp;To study the relation of C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR) and Body Mass Index (BMI) with diabetic retinopathy in patients enrolled from a tertiary care hospital.<br><strong>Study Design:&nbsp;</strong>Cross sectional comparative study.<br><strong>Place and Duration of Study:&nbsp;</strong>Centre for Research in Experimental and Applied Medicine (CREAM-1) at Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi in collaboration with Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi over a period of 6 months from Jan 2016 to Jun 2016.<br><strong>Material and Methods:&nbsp;</strong>There were 90 patients of diabetic retinopathy enrolled from AFIO. Their ages were in range 40-70 years. Their levels of ESR, CRP and BMI were assessed. These were then compared with 90 normal healthy controls from general population. Independent student’s t-test was applied for scale variables and Chi square test was applied for nominal variables.<br><strong>Results:</strong>&nbsp;Patients and controls were age and gender matched. Their mean ages were 60 ± 8.9&nbsp; years in patients and 59 ± 13.02 years in controls. In 90 patients enrolled 51 (56.7%) were males and 39 (43.3) were females. And in 90 controls considered 49 (54.4%) were males and 41 (45.6%) were females. Both scale variables gave following results ESR= 27.9 ± 6.96 in patients and 16.02 ± 7.6 in controls with a p-value of &lt;0.001 and BMI = 28.9 ± 2.94 in<br>patients and 26.02 ± 4.16 in controls with a p-value of &lt;0.001. CRP being a nominal variable gave p-value &lt;0.001. Diabetic retinopathy gave a significant positive association with all the three variables under study.<br><strong>Conclusion:&nbsp;</strong>There is a direct relationship of ESR and CRP with retinopathy signifying that inflammatory processes may be one of the underlying biochemical mechanisms in development of retinopathy. Moreover a direct relationship also exists between BMI and retinopathy indicating the contribution of weight gain in development of retinopathy.</p><p>&nbsp;</p> ER -