@article{Raza_Raza_Cheema_Cheema_Rafique_Khan_2021, title={DISAPPEARANCE OF ANTIBODIES IN COVID-19 MYTHS ORREALITY}, volume={71}, url={https://pafmj.org/PAFMJ/article/view/7940}, DOI={10.51253/pafmj.v1i1.7940}, abstractNote={<p><strong>Objective:</strong> To explore the disappearance of neutralizing antibodies from patients, their myths, and facts.</p> <p><strong>Study Design:</strong> Cross-sectional study.</p> <p><strong>Place and Duration of Study:</strong> Combined Military Hospital Multan Pakistan, from Jul 2021 to Aug 2021.</p> <p><strong>Methodology:</strong> A total of 100 blood samples were collected from 100 COVID-19 patients. These 100 patients were followed up for a period of 3 months. Antibodies were determined with the modified neutralization assay method and enzyme-linked immuno-sorbent assay (ELISA).</p> <p><strong>Results:</strong> The antibody level by NA and ELISA peaked on days 30-35 then decreased slightly. In multivariate analysis, patients aged 25-35, 36-56, and 57-84 years had a higher neutralizing antibody level than those aged 10-21 years. The patient with the worst clinical manifestation had a higher neutralizing antibody titer. In serum samples, IgG was undetectable at 18.3% and 11% and the geographical mean reciprocal titers dropped from 244 at 3-month period and neutralizing antibodies, the geographical mean reciprocal titers dropped from 874 at 3 months.</p> <p><strong>Conclusion:</strong> All COVID-19 patients were seropositive and significantly neutralizing antibody response. Neutralizing antibody levels depend on the time after the onset of symptoms, age, and severity of the disease.</p>}, number={Suppl-3}, journal={Pakistan Armed Forces Medical Journal}, author={Raza, Maqbool and Raza, Muhammed Ali and Cheema, De Emmal Asjad and Cheema, Maham Asjad and Rafique, Atif and Khan, Sarim Waleed}, year={2021}, month={Dec.}, pages={S530–33} }