@article{Nand_Feroz_Ahmed_Jafri_Sultan_Ahmed_2022, title={Comparison of the Efficacy of Intravenous Lignocaine and Intravenous Dexmedetomidine in Attenuation of Hemodynamic Stress Response to Laryngoscopy and Endotracheal Intubation}, volume={72}, url={https://pafmj.org/PAFMJ/article/view/6765}, DOI={10.51253/pafmj.v72i5.6765}, abstractNote={<p><strong><em>Objective:</em></strong> To study the effect of intravenous Lignocaine and Dexmedetomidine to attenuate cardiovascular stress reaction to laryngeal manipulation.</p> <p><strong><em>Study Design:</em></strong> Quasi-experimental study.</p> <p><strong><em>Place and Duration of Study: </em></strong>Department of Anesthesia, Combined Military Hospital, Peshawar Pakistan, from Oct 2019 to Apr 2020.</p> <p><strong><em>Methodology</em></strong><strong>: </strong>Patients were randomly divided into two Groups by lottery method. Seventy-three were in the intravenous Lignocaine-Group-(A), while 73 patients were in the intravenous Dexmedetomidine-Group-(B). Blood pressure, Pulse rate and ECG were documented at the start of general anaesthesia and after 1, 3 and 5 minutes of intubation. Efficacy was defined if systolic pressure and pulse remained within 20% of the patient’s native findings between 1 and 5 minutes after endotracheal intubation.</p> <p><strong><em>Results:</em></strong> A total of 146 patients were included in the stud. The mean baseline systolic BP of Group-A was 121.34±4.47mmHg and mean baseline diastolic BP was 80.31±3.57mmHg. While mean Baseline Systolic BP WAS 121.19±4.37mmHg in Group-B and mean baseline diastolic BP was 80.04±3.66mmHg. Efficacy was seen 74% patients of Group-A and 90.4% of Group-B (<em>p</em>=0.009).</p> <p><strong><em>Conclusion:</em></strong> Dexmedetomidine 1 microgram/kg blunts the cardiovascular sympathetic reaction to laryngeal manipulation more pronounced than Lignocaine 1.5 milligram/kg without any harmful outcomes.</p>}, number={5}, journal={Pakistan Armed Forces Medical Journal}, author={Nand, Raja and Feroz, Shizan Hamid and Ahmed, Mirza Sijeel and Jafri, Syed Asad Ullah and Sultan, Muhsan and Ahmed, Niaz}, year={2022}, month={Nov.}, pages={1686–89} }