@article{Faisal_Anwar_Khokhar_Sattar_Jamil_Jamal_2022, title={Anti-Inflammatory Activity of Crude Extract of Aesculus Indica in Comparison with Aspirin on Carrageenan Induced Paw Edema in Rats}, volume={72}, url={https://pafmj.org/PAFMJ/article/view/6634}, DOI={10.51253/pafmj.v72i3.6634}, abstractNote={<p><strong><em>Objective:</em></strong> To determine the anti-inflammatory activity of crude extract of <em>Aesculus Indica </em>in rat model.<strong><em>Study design: </em></strong>Comparative study<strong><em>Place and duration of study: </em></strong>Pharmacy Department, Bahauddin Zakria University, Multan, Pakistan, from May 2017 to October 2017.<strong><em>Methodology:</em></strong>Twenty four healthy male and female Wistar rats (200-220gm) were included in the study, each rat was given single injection of 0.1 ml of 1% carrageenan, in normal saline in sub-planter region of the right paw for induction of edema. The rats were randomly divided by lottery method in to four groups; Group-1 served as positive control; Group 2 and 3 received crude extract of <em>Aesculus Indica</em> 100 mg/kg and 300mg/kg respectively; Group 4 was given aspirin at the dose of 12 mg/kg. The measurement of paw volume was made immediately by displacement technique using the plathysmometer before and at 1st, 2nd, 3rd and 4th hour after the carrageenan injection.<strong><em>Results: </em></strong>The result of the study confirmed the anti-inflammatory action of crude extract of <em>Aesculus indica</em> both at 100 mg/kg and 300 mg/kg. When group 1 was compared with group 2, 3 and 4, it revealed significant difference with p-value 0.002, 0.042 and 0.002 respectively. Similarly, comparison of group 2 with group 3 showed significant difference with p-value 0.02 while insignificant difference was found between group 3 and 4. Significant difference of p-value 0.03 was found when group 2 and 4 were compared.<strong><em>Conclusion: </em></strong>Crude extract of the <em>Aesculus Indica</em> showed significant anti-inflammatory properties which at high doses were almost comparable with that of aspirin.</p>}, number={3}, journal={Pakistan Armed Forces Medical Journal}, author={Faisal, Rizwan and Anwar, Attia and Khokhar, Aamna and Sattar, Afeefah and Jamil, Ayesha and Jamal, Arif}, year={2022}, month={Jun.}, pages={822–25} }