@article{Shaukat_Kundi_Ullah_Waheed_Deeba_Iftikhar_2021, title={PROTECTIVE EFFECT OF SOYBEAN OIL ON MICE LUNG TISSUE INJURY AND ALVEOLAR HEMORRHAGE INDUCED BY BISPHENOL A}, volume={71}, url={https://pafmj.org/PAFMJ/article/view/5397}, DOI={10.51253/pafmj.v71i4.5397}, abstractNote={<p><strong>Objective:</strong> To evaluate histomorphological effects of Soybean oil supplementation on lung tissue injury and alveolar hemorrhage induced by Bisphenol A (BPA).</p> <p><strong>Study Design:</strong> Laboratory-based experimental study.</p> <p><strong>Place and Duration of Study:</strong> Anatomy department, Army Medical College, Rawalpindi and National Institute of Health, Islamabad, from Nov 2015 to Nov 2016.</p> <p><strong>Methodology:</strong> Forty (40) healthy BALB/c mice of 9-11 weeks of age, weighing between 30-37gm were housed in a controlled environment at National Institute of Health. Group 1 (10) was control group. Group 2 (10) was given a daily dose of 50 milligram/kilogram body weight of Bisphenol A and group 3 (10) was given a daily dose of 500 milligram of Soybean oil and group 4 (10) was concurrently given Bisphenol A and Soybean oil with daily doses of 50 milligram/kilogram body weight and 500 milligrams. After a period of 8 weeks, animals were dissected 24 hours after receiving the last dosage. Lung wet weight, animal weight and relative body tissue weight index (RTBWI) were calculated. Tissue processing & staining was done. Alveolar hemorrhage was histomorphologically and statistically analysed using SPSS-21.</p> <p><strong>Results:</strong> On microscopic examination, alveolar hemorrhage (AH) was observed in 10 (100%) group 2 specimens with increase in RTBWI and whereas only 5 (50%) of group 4 specimens had alveolar hemorrhage with slight improvement in relative body tissue weight index (RTBWI).</p> <p><strong>Conclusion:</strong> Bisphenol A (BPA) induced lung injury as evident by intraalveolar hemorrhage, blood vessel congestion and increased RTBWI ratio were ameliorated by concomitant administration of Soybean oil.</p>}, number={4}, journal={Pakistan Armed Forces Medical Journal}, author={Shaukat, Sadia and Kundi, Hina and Ullah, Qazi Waheed and Waheed, Nazish and Deeba, Farah and Iftikhar, Shazia}, year={2021}, month={Aug.}, pages={1336–40} }