@article{Komal_Mashhood_Farooq_Qayyum_2021, title={A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA}, volume={71}, url={https://pafmj.org/PAFMJ/article/view/4528}, DOI={10.51253/pafmj.v71i2.4528}, abstractNote={<p><strong>Objective:</strong> To compare the efficacy of Intradermal Tranexamic acid and topical 20% Azelaic acid cream in the treatment of melasma.</p> <p><strong>Study Design:</strong> Comparative prospective study.</p> <p><strong>Place and Duration of Study:</strong> Dermatology department, Combined Military Hospital Peshawar, from Sep 2018 to Mar 2019.</p> <p><strong>Methodology:</strong> A total of 116 female patients, at the outpatient department of dermatology at Combined Military Hospital Peshawar, were randomly assigned into two groups; group A (intradermal tranexamic acid) and group B (topical azelaic acid) by lottery method. Patients in group A received intradermal injection, while the participants of group B received topical azelaic acid only, fortnightly for 6 weeks. Melasma area severity index score was calculated for each patient in both groups at the start and at the end of the treatment.</p> <p><strong>Results:</strong> The mean Melasma area severity index score in group A (intradermal tranexamic acid) before and at 6 weeks of treatment was 7.10 ± 2.94 and 5.27 ± 2.44, respectively. The mean Melasma area severity index score in group B (topical azelaic acid) before and at 6 weeks of treatment was 7.56 ± 2.57 and 5.76 ± 2.89, respectively. Efficacy of intradermal tranexamic acid, as poor response, good response and excellent response was 27.6%, 41.4% and 31% respectively. While, efficacy of topical azelaic acid group as poor response, good response and excellent response was 62.1%, 20.7% and 17.2% respectively. The difference was statistically significant, (p=0.001).</p> <p><strong>Conclusion:</strong> It can be concluded that intradermal tranexamic acid is more effective as compared to topical 20% azelaic acid in..................</p>}, number={2}, journal={Pakistan Armed Forces Medical Journal}, author={Komal, Sayyida and Mashhood, Asher Ahmed and Farooq, Muhammad and Qayyum, Nida}, year={2021}, month={Apr.}, pages={494–97} }