@article{Abdullah_Hamid_Butt_2020, title={EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-IFLAMMATORY DRUGS}, volume={70}, url={https://pafmj.org/PAFMJ/article/view/4185}, abstractNote={<p><strong>Objective:</strong> To assess the effects of Prunus dulcis on gastric epithelium affected by nonsteroidal anti-inflammatory drugs.</p> <p><strong>Study Design:</strong> Laboratory based experimental study.</p> <p><strong>Place and Duration of Study:</strong> Anatomy Department, Army Medical College Rawalpindi, in collaboration with National Institute of Health (NIH), Islamabad, from Jan 2015 to Dec 2015.</p> <p><strong> Methodology:</strong> Forty healthy adult male and female (BALB/c strain) mice, 9-11 weeks age, weighting 30-40gm were used in the experiment and were kept in standard conditions in animal house. Animals were divided into four equal groups. Group A served as control, whereas group B, C and D served as experimental groups. Animals in all groups were given standard lab diet for 60 days. In addition to standard lab diet, experimental groups C and D were given almond oil (extracted without peel of almonds) and finely ground almonds (with peel), respectively, via oral gavage once a day for 60 days. At 60th day, 400 mg/kg of ASA solution was given, via oral gavage needle, to induce gastric ulcers in animals of experimental groups B, C and D. Type of epithelium and height of epithelium were assessed under Light Microscope.</p> <p><strong>Results:</strong> Height and type of epithelium improved in experimental groups C and D on intergroup comparison. Whereas group D showed improved protection as compared to group C.</p> <p><strong>Conclusion:</strong> Prunus dulcis provides protection, to gastric epithelium, against gastric ulcers induced by non-steroidal anti inflammatory drugs. In addition, finely granular almonds provided better protective outcome in comparison with almond oil.</p>}, number={2}, journal={Pakistan Armed Forces Medical Journal}, author={Abdullah, Muhammad Saad and Hamid, Shabnam and Butt, Shadab Ahmed}, year={2020}, month={Apr.}, pages={333–37} }