@article{Ali_Asif_Ali_Ahmad_Khadim_Akhtar_Abbasi_2020, title={ANALYSIS OF CD10 EXPRESSION IN THE EPITHELIAL LINING OF ODONTOGENIC CYSTS}, volume={70}, url={https://pafmj.org/PAFMJ/article/view/3785}, abstractNote={<p><strong>Objective:</strong> To investigate the expression of CD10 in the epithelium of Odontogenic keratocyst (OKC), Dentigerous and radicular cyst.</p> <p><strong> Study Design:</strong> Cross sectional analytical study.</p> <p><strong>Place and Duration of Study:</strong> Armed Forces Institute of Pathology, Rawalpindi, from Jan 2017 to Dec 2017.</p> <p><strong>Methodology:</strong> In this study, total of sixty cases were included with 20 of each Radicular cyst, Dentigerous cyst and Odontogenic keratocyst. Sections were stained with Haematoxylin and eosin (H&E) followed by Immuno-histochemistry (IHC) staining for CD10 antibody. SPSS version 20 was used to analyse the results. Expression of CD10 was evaluated.</p> <p><strong>Results:</strong> Out of total 60 cases, 41 (68.3%) were male and 19 (31.7%) were female patients with age ranges from 11 to 75 years. Mandible was reported in 38 (63.3%) of the cases followed by maxilla in 22 (36.7%) of the cases. In this study 7 (38%) cases of Odontogenic keratocysts showed negative epithelial CD10 expression as compared to Dentigerous cysts and Radicular cysts (45% & 25%). In Odontogenic keratocysts 9 (45%) of the cases showed basal layer of positivity of epithelium. While in dentigerous cyst 11 (55%) of the cases showed CD10 expression in the superficial layer of epithelium and the entire epithelium was positive in almost all 15 (75%) cases of radicular cyst. Intensity of staining was moderate in maximum number of the cases of Odontogenic keratocyst and radicular cyst (40% & 35%) as compared to dentigerous cyst (20%). There was a statistically significant association between odontogenic cysts and epithelial CD10 expression (p=0.001).</p> <p><strong>Conclusion:</strong> Majority of odontogenic cysts showed positivity for CD10 marker. Odontogenic keratocysts showed basal, DCs showed surface and RCs showed full thickness positivity for this marker.</p>}, number={Suppl-1}, journal={Pakistan Armed Forces Medical Journal}, author={Ali, Anam and Asif, Muhammad and Ali, Iram and Ahmad, Bismah and Khadim, Muhammad Tahir and Akhtar, Farhan and Abbasi, Muhammad Sajjad}, year={2020}, month={Jan.}, pages={S10–14} }