@article{Waseem_Iqbal_2018, title={COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION: Analgesic Efficacy in Advance Cancer Patients}, volume={68}, url={https://pafmj.org/PAFMJ/article/view/2265}, abstractNote={<p><strong>Objective</strong>: To determine the analgesic efficacy of lignocaine combined with dexamethasone and lignocaine<br>infusion in patients with advance cancer disease.<br>Study Design<strong>: Randomized controlled trial.</strong><br><strong>Place and Duration of Study</strong>: Pain centre Combined Military Hospital Rawalpindi, from Apr 2016 to Nov 2016.<br><strong>Material and Methods</strong>: Total 122 patients, 61 in each group, fulfilling the inclusion criteria were included in<br>this study after approval of the ethical committee. The technique used was non probability consecutive<br>sampling. Two groups were made; group-A received Lignocaine 2mg/kg and group-B Lignocaine 2mg/kg with<br>dexamethasone 0.15mg/kg in continuous infusion over 30 minutes. Both regimen were administered twice<br>weekly for a period of 12 weeks as an outdoor procedure. Numerical rating scale used to measure severity of<br>pain. Baseline and outcome parameters of all patients’ i.e. severity of persistent and breakthrough pain and<br>percentage relief of pain were recorded and compared at 12 weeks. Mean ± standard deviations were calculated<br>for quantitative variables, while qualitative variables presented in frequency and percentages. Chi-square test<br>used for qualitative variables while Independent sample t-test used to compare means. A p-value <0.05 was<br>considered statistically significant.<br><strong>Results</strong>: When results of group-B compared with group-A, there was a significant reduction in severity of<br>persistent pain from 5.68 ± 2.08 to 2.83 ± 1.01 (p-value <0.05), breakthrough pain from 5.90 ± 2.07 to 3.06 ± 1.09<br>(p-value <0.05). The percentage relief of pain was 45.08 ± 15.01 (%) when compared to baseline i.e. 23.35 ± 8.55 (%)<br>(p-value <0.05).<br><strong>Conclusion</strong>: Lignocaine with dexamethasone has shown to be effective in reducing complex cancer related pain<br>and disability when compared with Lignocaine alone.</p>}, number={5}, journal={Pakistan Armed Forces Medical Journal}, author={Waseem, Syed Majid and Iqbal, Amjad}, year={2018}, month={Oct.}, pages={1111–15} }