OUTCOME OF PATIENTS TREATED WITH BLADDER PRESERVATION PROTOCOL IN UROTHELIAL CARCINOMA OF URINARY BLADDER

  • Sameed Hussain Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abdus Samad Syed Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Fouzia Abdus Samad Fauji Foundation Hospital, Rawalpindi Pakistan
Keywords: Bladder preservation, Concurrent chemoradiotherapy, Organ preservation, Radical cystectomy, Urinary bladder carcinoma

Abstract

Objective: To explore trimodality treatment with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy as an alternative approach to neoadjuvant chemotherapy followed by radical cystectomy, for the treatment of non-metastatic muscle invasive bladder carcinoma.

Study Design: Retrospective observational study.

Place and Duration of Study: Combined Military Hospital Rawalpindi Pakistan, from 2006 and 2015.

Methodology: A total of 122 patients were evaluated in a retrospective manner. Primary endpoint was overall survival. Patients received four courses of neoadjuvant chemotherapy followed by radical concurrent chemoradiotherapy with Cisplatin as radiation sensitizer.

Result: 5-year overall survival was 80 (66%) in this population and a complete response following completion of treatment was seen in 93 (76.3%) patients. Subset analysis showed markedly increased 5-year overall survival of around 104 (85%) in patients having complete response after neoadjuvant chemotherapy.

Conclusion: The study concludes that bladder preservation is an acceptable alternative to radical cystectomy in selected population especially among those who had a complete response to the initial four courses of chemotherapy.

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Published
2021-12-31
How to Cite
Hussain, S., Syed, A., & Samad, F. (2021). OUTCOME OF PATIENTS TREATED WITH BLADDER PRESERVATION PROTOCOL IN UROTHELIAL CARCINOMA OF URINARY BLADDER. PAFMJ, 71(6), 2118-21. https://doi.org/10.51253/pafmj.v71i6.5847
Section
Original Articles