Acute Kidney Injury in Plasmodium Falciparum Malaria; Field Hospital Experience

Abstract

Malaria is most common health problem in tropical areas that can lead to fatal complications including acute kidney injury. Plasmodium falciparum infection is one of leading cause of complicated malaria leading to death. Although the pathogenesis of acute kidney injury is not fully understood, however, blockage of renal microcirculation due to sequestration of red blood cells, immune mediated glomerular injury, and hypovolemia, play a pivotal role in causing acute of kidney dysfunction. Acute tubular necrosis is most found on histological examination. Acute kidney dysfunction induced by malaria infection can cause irreversible damage if not managed properly. Therefore, early diagnosis and management with dialysis, plays important role in saving life.