Comparing Oral Moxifloxacin and Ciprofloxacin Ear Drops Versus Ciprofloxacin Ear Drops Only in Patients with Active Mucosal Chronic Otitis Media

Abstract

Objective: To compare the effects of Oral Moxifloxacin and topical antibiotic ear drops in patients with active mucosal chronic otitis media.

Study Design: Comparative prospective study.

Place and Duration of Study: Combined Military Hospital Bahawalpur, from May 2018 to Apr 2020.

Methodology: A total of 100 patients with Active (mucosal) Chronic Otitis Media were included in the study. These patients were divided into two groups. The first group received oral Moxifloxacin and topical Ciprofloxacin ear drops, while the second group only received topical ciprofloxacin ear drops. Clinical success was compared in both groups regarding patients becoming asymptomatic and having a dry ear on examination.

Results: 45(90%) patients in combined treatment while 35 (70%) in the topical ciprofloxacin ear drops group became asymptomatic. The Chi-square test was applied (6.25). The p-value was .124. We found that oral Moxifloxacin, in addition to topical Ciprofloxacin ear drops, is a superior treatment option in decreasing the symptoms of tubotympanic chronic otitis media (COM) than the topical ciprofloxacin ear drops when used alone.

Conclusion: Moxifloxacin is an effective drug in controlling symptoms of tubotympanic chronic supportive otitis media, and its combination with topical ciprofloxacin ear drops is superior to the ciprofloxacin ear drops when used alone.