PREDICTORS OF MORTALITY WITHIN 8 WEEKS AFTER ENDOSCOPIC TREATMENT OF GASTRIC VARICEAL BLEED WITH N-BUTYL 2-CYANOACRYLATE IN CIRRHOTIC PATIENTS

Mahmood Ahmad; Yasir Mahmud; Sidra Rasheed; Muhammad Muaaz; Muhammad Naeem Afzal; Muhammad Arif Nadeem

doi:10.51253/pafmj.v71i4.3281

Authors

Mahmood Ahmad Services Institute of Medical Sciences, Lahore Pakistan
Yasir Mahmud Services Institute of Medical Sciences, Lahore Pakistan
Sidra Rasheed Services Institute of Medical Sciences, Lahore Pakistan
Muhammad Muaaz Services Institute of Medical Sciences, Lahore Pakistan
Muhammad Naeem Afzal Services Institute of Medical Sciences, Lahore Pakistan
Muhammad Arif Nadeem Services Institute of Medical Sciences, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i4.3281

Keywords:

Cirrhosis, N-butyl 2-Cyanoacrylate, Gastric Varices, Predictors, Mortality, Outcome

Abstract

Objective: To assess the predictors associated with mortality within 8 weeks in patients undergoing endoscopic N-butyl-2- cyanoacrylate treatment.

Study Design: Prospective comparative study.

Place and Duration of Study: Department of Gastroenterology, Services Institute of Medical Sciences, Lahore Pakistan, from Mar 2018 to Mar 2019.

Methodology: A total of 106 patients of gastric variceal bleed were enrolled in the study. Tissue glue was injected into the varix endoscopically and mortality within 8 weeks after endoscopic intervention was noted.

Results: Among the enrolled patients, 65 (61.3%) were male and 41(38.7%) were female. Mortality was noted in 19 (17.9%) patients within 8 weeks after endoscopic therapy. Chi-square analysis showed creatinine >1.5, Child Pugh score >9, MELD score >18, re-bleeding within 7 days, low blood pressure <90/60 at presentation and hepatic encephalopathy as significant predictors of mortality (p<0.005).

Conclusion: Cirrhotic patients undergoing endoscopic injection of gastric varix with N-butyl 2-cyanoacrylate after gastric variceal bleed have high risk of death within 8 weeks.