EFFECTS OF PROPOFOL INFUSION VERSUS SEVOFLURANE ON HEMODYNAMIC RESPONSE DURING CARDIOPULMONARY BYPASS IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT SURGERY

Abstract

Objective: The aim of this study was to compare hemodynamic effects of propofol with that of sevoflurane during cardiopulmonary bypass time in patients undergoing coronary artery bypass surgery to avoid high lactate level which is an indicator of poor prognosis.

Study Design: Randomized control trial.

Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, from Jan 2017 to Aug 2017.

Material and Methods: Hemodynamic of 120 patients during CPB were studied after either propofol or Sevoflurane was applied with initiation of a Standard cardiopulmonary bypass technique, applying cross clamp, administering cardioplegia and allow time to develop stable perfusion pressure. Base line lactate level from initial arterial blood gases was recorded, total bypass time, cross clamp time, Noradrenalin dose, flow rate, mean arterial pressure during CPB and post rewarming lactate level were recorded for all patients.

Results: There was no significant difference in lactate level and noradrenalin dose that given in two groups when rewarming was established. Propofol group showed a significant lower MAP 63.1 ± 2.6 mmHg in comparison to sevoflurane group 69.5 ± 5.3 mmHg and significant higher flow rate p-value <0.001.

Conclusion: Patients in both groups remained hemodynamically stable with lower MAP in propofol group requiring higher flow rate.