EFFECT OF FLAXSEED OIL ON LIPOFUNDIN-INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS

Flaxseed Oil And Lipofundin-Induced Hepatotoxicity

Abstract

Objective: To find out the preventive effect of flaxseed oil on the hepatic damage produced by the Lipofundin, a soya-bean based lipid emulsion used in parenteral therapies.
Study Design: Experimental study.
Place and Duration of Study: The study was carried out at the University of Health Sciences, Lahore for a period of one year, from Jan 2015 to Dec 2015.
Material and Methods: Experimental study has been performed to study the effect of flaxseed oil on the lipofundin induced hepatotoxicity. Thirty-two male adult albino rats were obtained from animal house of University of Health Sciences, Lahore and divided into four equal groups. Group A (control group) was given flaxseed oil 3ml/kg intraperitonially daily for 10 days and sacrificed on day 11. Group B was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 11. Group C was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 21. Group D was given Lipofundin 2ml/kg intravenously for 10 days followed by Flaxseed oil 3ml/kg intraperitonially for 10 days and sacrificed on day 21.
Results: Flaxseed oil was observed to restore the hepatic tissue damage caused by the lipofundin administration.
Conclusion: Flaxseed oil has an ameliorative effect on the hepatic tissue damage caused by the   Lipofundin.Hence its use may help prevent hepatic tissue damage caused by lipofundin used in parenteral therapies.

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