RANITIDINE POTENTIATES THE EFFECT OF METOCLOPRAMIDE ON GASTROINTESTINAL MOTILITY IN RABBITS

Metoclopramide On Gastric Motility

Abstract

Objective: To explore the synergistic potential of ranitidine on prokinetic activity of metoclopramide on isolated duodenal model of rabbit.
Study Design: Laboratory based randomized controlled trial.
Place and Duration of Study: Multi-disciplinary Laboratory, Army Medical College, Rawalpindi with study duration of 12 months.
Material and Methods: Dose response curve of ranitidine and metoclopramide were constructed by adding cumulatively increasing concentrations of the two drugs on isolated duodenum of rabbits separately. A fixed dose of ranitidine was then selected for studying its potentiating effect on increasing concentrations of metoclopramide on isolated duodenum of rabbits utilizing iWorx Data acquisition unit AHK/214.
Results: Ranitidine enhances the prokinetic effect of metoclopramide.
Conclusion: Ranitidine enhances the contractile effect of the gut in vitro and potentiates the prokinetic effect of metoclopramide. So we conclude that ranitidine is a better choice for patients suffering from gastroesophageal reflux disease (GERD) along with gastroparesis as it enhances the prokinetic effect of metoclopramide.