PAKISTAN ARMED FORCES
MEDICAL JOURNAL (Category Y)

A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 65, No. 2, APRIL 2015

PLACENTAL MORPHOLOGY AT DIFFERENT MATERNAL HEMOGLOBIN LEVELS: A HISTOPATHOLOGICAL STUDY

Nazma Kiran, Alia Zubair, Tariq Masood Malik*, Muhammad Ayyub**, Iqbal Muhammad Khan**

Abstract

Objective: To evaluate the histopathological parameters of the placenta like weight, infarct and syncytial knots, at different maternal hemoglobin levels, in both qualitative and quantitative manner.
Study design: Descriptive study
Place and Duration of Study: Army Medical College, National University of Sciences and Technology in collaboration with Department of Obstetrics and Gynecology, Military Hospital, Rawalpindi, Pakistan, from December 2011 to November 2012.
Patients and Methods: A total of 75 placentas were included, that were collected from full term mothers at the time of childbirth. Placental weight was taken without umbilical cord and gross placental infarcts were noted. Samples of placental tissue were taken and stained by haematoxylin and eosin (H&E). Microscopic study was done to evaluate placental infarcts and syncytial knots.
Results: Mean placental weight at normal and low maternal hemoglobin was 581.67± 83.97g and 482.58 ± 104.74g respectively. Gross placental infarcts were found in all cases having low maternal hemoglobin concentration (60% cases). Syncytial knots were found in all placentas but they were considerably more at decreasing levels of maternal hemoglobin (19.79 ± 5.22).
Conclusion: The present study showed decrease in placental weight, increase in placental infarcts and syncytial knot hyperplasia at low maternal hemoglobin concentration, displaying adaptive alterations.

Keywords : Low hemoglobin concentration, Placental infarcts, Placental morphology, Placental weight, Syncytial knots.



Creative Commons License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.