A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 68, No. 4, AUGUST 2018

Catheter-Based Renal Denervation In Patients With Uncontrolled Hypertension In The Absence Of Antihypertensive Medications (SPYRAL HTN-OFF MED): A Randomised, Sham-Controlled, Proof-Of-Concept Trial

Dr Fahad Khan,


We have read, with great interest, the original article titled ‘Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): A randomised, sham-controlled, proof-of-concept trial’ published in ‘The Lancet’ (2017; 7: 0140-6736)1. In this clinical trial efficacy of renal denervation in patients with mild to moderate resistant hypertension has been demonstrated. Although previous trial ‘SYMPLICITY HTN-3’2 had confirmed the efficacy of renal denervation by keeping the patients ‘OFF-ANTI HYPER-TENSIVE MEDICATIONS’ and overcoming other limitations that were incriminated to be the probable causes of negative results of previous trials3. No adverse effects of the procedure occurred during or at the end of the clinical trial.


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