PAKISTAN ARMED FORCES
MEDICAL JOURNAL (Category Y)

A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 68, No. 5, OCTOBER 2018

EVALUATION OF SINGLE PREOPERATIVE DOSE OF PREGABALIN IN TERMS OF POSTOPERATIVE PAIN AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Adeel Qamar Ghuman, Sohail Saqib Chatha*, Mahwish Farooq**, Maqbool Ahmad***

Abstract

Objective: Evaluation of single preoperative dose of pregabalin in terms of postoperative pain after laparoscopic cholecystectomy.
Study Design: Randomized controlled trial (RCT).
Place and Duration of Study: Study was conducted in Surgical Department of Military Hospital Rawalpindi over a period of one year fromJan 2013 to Dec 2013.
Material and Methods: One hundred patients (50 in each group) were included in this study. They were     divided into two groups. Group-A was given pregabalin and group-B was given placeboafter laparoscopic cholecystectomy.
Results: Mean age was 38.2 ± 11.0 years in group A and 36.9 ± 11.7 years in group B. Regarding distribution of gender, 14 patients (28.0%) in group-A and 17 patients (34.0%) in group-B were males while 36 patients (72.0%) in group-A and 33 patients (66.0%) in group-B were females. Mean visual analogue score at 24 hours was 4.98 ± 1.87 and 6.58 ± 2.03 in group-A and B, respectively. The difference between two group was statistically significant (p<0.001). Analgesia was required in 17 patients (34.0%) in group-A and 37 patients of group-B.
Conclusion: A single preoperative oral dose of pregabalin 150 mg was foundvery effective method for reducing postoperative pain in patients undergoing laparoscopic cholecystectomy

Keywords : Laparoscopic cholecystectomy, Postoperative pain, Pregabalin.



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