PAKISTAN ARMED FORCES
MEDICAL JOURNAL (Category Y)

A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 68, No. 4, AUGUST 2018

THROMBOPHILIA PROFILE IN YOUNG PATIENTS OF CEREBROVASCULAR ACCIDENT-- AN INSTITUTION BASED STUDY

Amna Khalid, Saleem Ahmed Khan, Nasirudin, Wasim Alamgir*, Rabia Anwar**

Abstract

Objective: To find out frequency of different causes of thrombophilia in young patients of cerebrovascular accidents. 
Study Design: Cross sectional descriptive study. 
Place and Duration of Study: This study was carried out at department of haematology, Army Medical College, Military Hospital and Armed Forces Institute of Pathology Rawalpindi, from Nov 2016 to Nov 2017. 
Material and Methods: Young patients aged 18 to 45 years were included in this study. Relevant history was obtained and general physical examination was done. Base line investigations included, complete blood count, prothrombin time, activated partial thromboplastin time and lipid profile. Tests for inherited thrombophilia (protein C, protein S, antithrombin, factor V leiden and prothrombin gene mutation) were carried out along with anticardiolipin, antiphospholipid antibodies and plasma homocysteine levels were measured to rule out, thrombophilia as a cause of CVA in young patients. The frequencies, of various causes of thrombophilia in CVA patients were analyzed. 
Results: Out of 30 patients there were 26 (86.7%) males and 04 (13.3%) females. The mean age was 36.6 years. The results of protein C, protein S, prothrombin gene mutation, antiphospholipid anticardiolipin antibodies, antithrombin and factor V leiden mutation were normal in all 30 patients. However, plasma homocysteine levels were raised in 20 patients with mean of 22.90. A statistical significance between the homocysteine levels and male genders was observed in this study. 
Conclusion: Raised plasma homocysteine levels were most common finding in young patients of CVA. All other laboratory parameters of thrombophilia were negative in young patients of CVA in our study.

Keywords : Antithrombin, Anticardiolipin and Antiphospholipid antibodies, Cerebrovascular accidents, Factor v laiden, Homocystein, Protein C, Protein S, Prothrombin gene.



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