PAKISTAN ARMED FORCES
MEDICAL JOURNAL (Category Y)

A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 68, No. 2, APRIL 2018

IN VITRO SUSCEPTIBILITY OF MRSA CLINICAL ISOLATES TO CEFTAROLINE

Muhammad Aurangzeb, Raja Kamran Afzal*, Muhammad Abid*, Aamir Hussain*, Fauzia Aitazaz**, Rozina Khaliq*

Abstract

Objective: To determine the in vitro susceptibility of MRSA clinical isolates to ceftaroline, using interpretation of zones of inhibition by disk diffusion method.
Study Design: Descriptive cross sectional.
Place and Duration of Study: The study was carried out at the Department of Microbiology, Combined Military Hospital Peshawar, from Jan to Dec 2014.
Material and Methods: To carry out this descriptive cross sectional study, clinical specimens were obtained from indoor and outdoor patients of Combined Military Hospital Peshawar. All the isolates of MRSA cultured with CLSI guidelines and identified with standard microbiological procedures, from clinical specimens of pus, body fluid, urine, tissue and blood were included in the study. The antimicrobial susceptibility pattern of ceftaroline was determined according to CLSI guidelines. The data was analyzed in SPSS (version 19) software.
Results: Out of a total 190 MRSA isolates, 183 (96.3%) were susceptible to ceftaroline in vitro, whereas 5 (2.6%) were resistant and 2 (1.1%) were intermediate in their response to ceftaroline.
Conclusion: Ceftaroline can be used effectively against infections caused by MRSA as it has shown very high in vitro activity against MRSA strains of clinical origin.

Keywords : Antimicrobial susceptibility, Ceftaroline, MRSA.



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