PAKISTAN ARMED FORCES
MEDICAL JOURNAL (Category Y)

A Journal of Army Medical & Dental Corps

Being published since 1956

ISSN (online) 2411-8842
ISSN (print) 0030-9648

VOL 67, No. 6, DECEMBER 2017

EFFECT OF FLAXSEED OIL ON LIPOFUNDIN-INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS

Lubna Malik, Mohammad Tahir, Khalid Pervez Lone, Waqas Latif

Abstract

Objective: To find out the preventive effect of flaxseed oil on the hepatic damage produced by the Lipofundin, a soya-bean based lipid emulsion used in parenteral therapies.
Study Design: Experimental study.
Place and Duration of Study: The study was carried out at the University of Health Sciences, Lahore for a period of one year, from Jan 2015 to Dec 2015.
Material and Methods: Experimental study has been performed to study the effect of flaxseed oil on the lipofundin induced hepatotoxicity. Thirty-two male adult albino rats were obtained from animal house of University of Health Sciences, Lahore and divided into four equal groups. Group A (control group) was given flaxseed oil 3ml/kg intraperitonially daily for 10 days and sacrificed on day 11. Group B was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 11. Group C was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 21. Group D was given Lipofundin 2ml/kg intravenously for 10 days followed by Flaxseed oil 3ml/kg intraperitonially for 10 days and sacrificed on day 21.
Results: Flaxseed oil was observed to restore the hepatic tissue damage caused by the lipofundin administration.
Conclusion: Flaxseed oil has an ameliorative effect on the hepatic tissue damage caused by the   Lipofundin.Hence its use may help prevent hepatic tissue damage caused by lipofundin used in parenteral therapies.

Keywords : Flaxseed oil, Hepatotoxicity, Lipofundin.



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