EFFECT OF MUFA ENRICHED EXTRA VIRGIN OLIVE OIL ON GLYCEMIC STATUS AND INSULIN SECRETION IN DIABETIC RATS

Effect of Olive Oil On Glycemic Status

Abstract

Objective: To evaluate the effect of monounsaturated fatty acid enriched extra virgin olive oil on glycemic status and insulin secretion in diabetic rats.
Study Design: Randomized Control Trial.
Place and Duration of Study: Department of Biochemistry, Army Medical College, Rawalpindi in collaboration with Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi and National Institute of Health, Islamabad from March 2010 to June 2011.
Material and Methods: Eighty albino rats of Sprague-dawley strain weighing 200-250 g were randomly divided into two groups of 40 rats each. Rats were made diabetic by injecting streptozotocin. Group 1 and Group II were given normal rodent diet and extra virgin olive oil supplemented diet respectively for 06 weeks. At the end of experimentation, fasting blood glucose, glycosylated hemoglobin and insulin were measured.
Results: There was significant decrease of fasting blood glucose & glycosylated hemoglobin and significant increase of serum insulin of group II rats when it was compared with group I (control).
Conclusion: Monounsaturated fatty acids enriched extra virgin olive oil can significantly improve glycemic status and serum insulin in diabetic rats.